Abstract: Sampling from high-dimensional probability distributions is a fundamental and challenging problem encountered throughout science and engineering. One of the most popular approaches to tackle such problems is the Markov chain Monte Carlo (MCMC) paradigm. While MCMC algorithms are often simple to implement and widely used in practice, analyzing the rate of convergence to stationarity, i.e. the "mixing time", remains a challenging problem in many settings. I will describe a new technique based on pairwise correlations called "spectral independence", which has been…