Abstract: Many algorithms take prohibitively long to run on modern, large data sets. But even in complex data sets, many data points may be at least partially redundant for some task of interest. So one might instead construct and use a weighted subset of the data (called a “coreset”) that is much smaller than the original dataset. Typically running algorithms on a much smaller data set will take much less computing time, but it remains to understand whether the output…

Abstract: Bulk sequencing of tumor DNA is a popular strategy for uncovering information about the spectrum of mutations arising in the tumor, and is often supplemented by multi-region sequencing, which provides a view of tumor heterogeneity. The statistical issues arise from the fact that bulk sequencing makes the determination of sub-clonal frequencies, and other quantities of interest, difficult. In this talk I will discuss this problem, beginning with its setting in population genetics. The data provide an estimate of the…

Abstract:   Privacy-preserving data analysis has been put on a firm mathematical foundation since the introduction of differential privacy (DP) in 2006. This privacy definition, however, has some well-known weaknesses: notably, it does not tightly handle composition. This weakness has inspired several recent relaxations of differential privacy based on the Renyi divergences. We propose an alternative relaxation we term "f-DP", which has a number of nice properties and avoids some of the difficulties associated with divergence based relaxations. First, f-DP preserves…

Abstract: We introduce the diffusion K-means clustering method on Riemannian submanifolds, which maximizes the within-cluster connectedness based on the diffusion distance. The diffusion K-means constructs a random walk on the similarity graph with vertices as data points randomly sampled on the manifolds and edges as similarities given by a kernel that captures the local geometry of manifolds. Thus the diffusion K-means is a multi-scale clustering tool that is suitable for data with non-linear and non-Euclidean geometric features in mixed dimensions. Given…