Abstract:  Massive data collection holds the promise of a better understanding of complex phenomena and ultimately, of better decisions. An exciting opportunity in this regard stems from the growing availability of perturbation / intervention data (drugs, knockouts, overexpression, etc.) in biology. In order to obtain mechanistic insights from such data, a major challenge is the development of a framework that integrates observational and interventional data and allows predicting the effect of yet unseen interventions or transporting the effect of interventions…

Abstract: The contextual bandit is a sequential decision making problem in which a learner repeatedly selects an action (e.g., a news article to display) in response to a context (e.g., a user’s profile) and receives a reward, but only for the action they selected. Beyond the classic explore-exploit tradeoff, a fundamental challenge in contextual bandits is to develop algorithms that can leverage flexible function approximation to model similarity between contexts, yet have computational requirements comparable to classical supervised learning tasks…

Abstract: The Bayesian approach to inverse problems has become very popular in the last decade after seminal work by Andrew Stuart (2010) and collaborators. Particularly in non-linear applications with PDEs and when using Gaussian process priors, this can leverage powerful MCMC methodology to tackle difficult high-dimensional and non-convex inference problems. Little is known in terms of rigorous performance guarantees for such algorithms. After laying out the main ideas behind Bayesian inversion, we will discuss recent progress providing both statistical and…

Abstract: One of the most basic problems in statistics is the estimation of the mean of a random vector, based on independent observations. This problem has received renewed attention in the last few years, both from statistical and computational points of view. In this talk we review some recent results on the statistical performance of mean estimators that allow heavy tails and adversarial contamination in the data. The basic punchline is that one can construct estimators that, under minimal conditions,…

Abstract:  In this talk we discuss the idea of data- driven regularisers for inverse imaging problems. We are in particular interested in the combination of mathematical models and purely data-driven approaches, getting the best from both worlds. In this context we will make a journey from “shallow” learning for computing optimal parameters for variational regularisation models by bilevel optimization to the investigation of different approaches that use deep neural networks for solving inverse imaging problems. Bio: Carola-Bibiane Schönlieb is Professor of…

Abstract: Wasserstein-based distributional robust optimization problems are formulated as min-max games in which a statistician chooses a parameter to minimize an expected loss against an adversary (say nature) which wishes to maximize the loss by choosing an appropriate probability model within a certain non-parametric class. Recently, these formulations have been studied in the context in which the non-parametric class chosen by nature is defined as a Wasserstein-distance neighborhood around the empirical measure. It turns out that by appropriately choosing the…

Abstract:  As datasets continue to grow in size, in many settings the focus of data collection has shifted away from testing pre-specified hypotheses, and towards hypothesis generation. Researchers are often interested in performing an exploratory data analysis in order to generate hypotheses, and then testing those hypotheses on the same data; I will refer to this as 'double dipping'. Unfortunately, double dipping can lead to highly-inflated Type 1 errors. In this talk, I will consider the special case of hierarchical…