Abstract:  Phylogenetic trees are mathematical objects of great importance used to model hierarchical data and evolutionary relationships with applications in many fields including evolutionary biology and genetic epidemiology. Bayesian phylogenetic inference usually explore the posterior distribution of trees via Markov Chain Monte Carlo methods, however assessing uncertainty and summarizing distributions remains challenging for these types of structures. In this talk I will first introduce a distance metric on the space of unlabeled ranked tree shapes and genealogies. I will then…

Abstract: We consider the problem of sequential probability assignment in the Gaussian setting, where one aims to predict (or equivalently compress) a sequence of real-valued observations almost as well as the best Gaussian distribution with mean constrained to a general domain. First, in the case of a convex constraint set K, we express the hardness of the prediction problem (the minimax regret) in terms of the intrinsic volumes of K. We then establish a comparison inequality for the minimax regret…

Abstract: Contemporary generative models used in the context of unsupervised learning have primarily been designed around the construction of a map between two probability distributions that transform samples from the first into samples from the second. Advances in this domain have been governed by the introduction of algorithms or inductive biases that make learning this map, and the Jacobian of the associated change of variables, more tractable. The challenge is to choose what structure to impose on the transport to…

Abstract: Energy-based models are a recent class of probabilistic generative models wherein the distribution being learned is parametrized up to a constant of proportionality (i.e. a partition function). Fitting such models using maximum likelihood (i.e. finding the parameters which maximize the probability of the observed data) is computationally challenging, as evaluating the partition function involves a high dimensional integral. Thus, newer incarnations of this paradigm instead train other losses which obviate the need to evaluate partition functions. Prominent examples include score matching (in which we fit…

Abstract: The Paley graph is a classical number-theoretic construction of a graph that is believed to behave "pseudorandomly" in many regards. Accurately bounding the clique number of the Paley graph is a long-standing open problem in number theory, with applications to several other questions about the statistics of finite fields. I will present recent results studying the application of convex optimization and spectral graph theory to this problem, which involve understanding the extent to which the Paley graph is "spectrally…

Abstract: Sampling from high-dimensional probability distributions is a fundamental and challenging problem encountered throughout science and engineering. One of the most popular approaches to tackle such problems is the Markov chain Monte Carlo (MCMC) paradigm. While MCMC algorithms are often simple to implement and widely used in practice, analyzing the rate of convergence to stationarity, i.e. the "mixing time", remains a challenging problem in many settings. I will describe a new technique based on pairwise correlations called "spectral independence", which has been…