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Statistics and Data Science Seminar Susan Murphy (Harvard)

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Statistics and Data Science Seminar Alex Bloemendal (Broad Institute)

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Challenges in Developing Learning Algorithms to Personalize Treatment in Real Time

Susan Murphy (Harvard)
E18-304

Abstract:  A formidable challenge in designing sequential treatments is to  determine when and in which context it is best to deliver treatments.  Consider treatment for individuals struggling with chronic health conditions.  Operationally designing the sequential treatments involves the construction of decision rules that input current context of an individual and output a recommended treatment.   That is,…

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Genome-wide association, phenotype prediction, and population structure: a review and some open problems

Alex Bloemendal (Broad Institute)
E18-304

Abstract: I will give a broad overview of human genetic variation, polygenic traits, association studies, heritability estimation and risk prediction. I will focus on the dual correlation structures of linkage disequilibrium and population structure, discussing how these both confound and enable the various analyses we perform. I will highlight an important open problem on the…

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