Abstract:  A formidable challenge in designing sequential treatments is to  determine when and in which context it is best to deliver treatments.  Consider treatment for individuals struggling with chronic health conditions.  Operationally designing the sequential treatments involves the construction of decision rules that input current context of an individual and output a recommended treatment.   That is,…

Abstract: I will give a broad overview of human genetic variation, polygenic traits, association studies, heritability estimation and risk prediction. I will focus on the dual correlation structures of linkage disequilibrium and population structure, discussing how these both confound and enable the various analyses we perform. I will highlight an important open problem on the…