Abstract: We present an algorithm for creating high resolution anatomically plausible images that are consistent with acquired clinical brain MRI scans with large inter-slice spacing. Although large databases of clinical images contain a wealth of information, medical acquisition constraints result in sparse scans that miss much of the anatomy. These characteristics often render computational analysis impractical as standard processing algorithms tend to fail when applied to such images. Our goal is to enable application of existing algorithms that were originally…

Abstract: We consider the Sherrington-Kirkpatrick model of spin glasses with ferromagnetically biased couplings. For a specific choice of the couplings mean, the resulting Gibbs measure is equivalent to the Bayesian posterior for a high-dimensional estimation problem known as "Z2 synchronization". Statistical physics suggests to compute the expectation with respect to this Gibbs measure (the posterior mean in the synchronization problem), by minimizing the so-called Thouless-Anderson-Palmer (TAP) free energy, instead of the mean field (MF) free energy. We prove that this identification…

Abstract: The perceptron is a toy model of a simple neural network that stores a collection of given patterns. Its analysis reduces to a simple problem in high-dimensional geometry, namely, understanding the intersection of the cube (or sphere) with a collection of random half-spaces. Despite the simplicity of this model, its high-dimensional asymptotics are not well understood. I will describe what is known and present recent results. This is a joint work with Jian Ding. Biography: Nike Sun is a…

Abstract: Over 500K scientific articles have been published since 1999 with the word “network” in the title. And the vast majority of these report network summary statistics of one type or another. However, these numbers are rarely accompanied by any quantification of uncertainty. Yet any error inherent in the measurements underlying the construction of the network, or in the network construction procedure itself, necessarily must propagate to any summary statistics reported. Perhaps surprisingly, there is little in the way of…

Abstract: Total variation denoising (TVD) is a popular technique for nonparametric function estimation. I will first present a theoretical optimality result for univariate TVD for estimating piecewise constant functions. I will then present related results for various extensions of univariate TVD including adaptive risk bounds for higher-order TVD (also known as trend filtering) as well as a multivariate extension via the Hardy-Krause Variation which avoids the curse of dimensionality to some extent. I will also mention connections to shape restricted…

Abstract: In this work we consider bootstrap-based inference methods for functions of the parameter vector in the presence of many moment inequalities where the number of moment inequalities, denoted by p, is possibly much larger than the sample size n. In particular this covers the case of subvector inference, such as the inference on a single component associated with a treatment/policy variable of interest. We consider a min-max of (centered and non-centered) Studentized statistics and study the properties of the…

Abstract: The talk will focus on optimization on the high-dimensional sphere when the objective function is a linear combination of homogeneous polynomials with standard Gaussian coefficients. Such random processes are called spherical spin glasses in physics, and have been extensively studied since the 80s. I will describe certain geometric properties of spherical spin glasses unique to the full-RSB case, and explain how they can be used to design a polynomial time algorithm that finds points within small multiplicative error from…