Regression-Robust Designs of Controlled Experiments
Achieving balance between experimental groups is a cornerstone of causal inference. Without balance any observed difference may be attributed to a difference other than the treatment alone. In controlled/clinical trials, where the experimenter controls the administration of treatment, complete randomization of subjects has been the golden standard for achieving this balance because it allows for unbiased and consistent estimation and inference in the absence of any a priori knowledge or measurements. However, since estimator variance under complete randomization may be…